What is a Loss? Loss[los]noun1.A Loss is an injury or damage that is covered by an insurance Policy. Losses can be partial, like when wind damages part of a roof, or total, as when an automobile is “totaled” in a collision. Share | Have A Question About This Topic? Name Email Address Question Thank you! Oops! Related Contents If You're In An Accident Do you know what to do if you're in a car accident? What is Underwriting? Do you know what Underwriting is? Protecting Those Who Matter Most The importance of life insurance, how it works, and how much coverage you need.